Taxol is an anticancer drug obtained from Vinca rosea.

The Pacific yew is an evergreen tree that grows in the Pacific Northwest. The Pacific yew has a fleshy, poisonous fruit. Recently, taxol, a substance found in the bark of the Pacific yew, was discovered to be a promising new anticancer drug.

A

Taxol is poisonous when taken by healthy people.

B

Taxol has cured people from various diseases.

C

People should not eat the fruit of the Pacific yew.

D

The Pacific yew was considered worthless until taxol was discovered.

In an experimental study of the effects of a new drug on depression a double-blind control technique is used, which of the following persons should not be informed as to which drug, experimental or placebo is being administered to each individual research participant?
1. Research participants in the experimental group.
2. Research participants in the control group.
3. Persons administering the drug.
4. Persons evaluating the drug effect.
Select the correct answer:

A

Only 2

B

1 and 3

C

1, 2 and 4

D

All of these

A drug that is highly effective in treating many types of infection can,at present,be obtained only from the bark of the ibora , a tree that is quite rare in the wild. It takes the bark of 5000 trees to make one kilogram of the drug. It follows, therefore, that continued production of the drug must inevitably lead to the ibore's extinction. Which of the following,if true, most seriously weakens the arguments above ?

A

The drug made from the ibora bark is dispensed to doctors from a central authority

B

The drug made from the ibora bark is expensive to produce

C

The leaves of the ibora are used in a number of medical products

D

The ibora can be propagated from cuttings and grown under cultivation

Which of these nanoprobes can detect cancer cell nuclei as well as deliver anticancer drug directly to the nuclei region?

A

PAA modified BaYbF5:Tm nanoprobes

B

Superparamagnetic iron oxide nanoprobes

C

PEG modified BaGdF5:YB/ER UCNPs

D

Er/Yb doped NaYF4 core and NaGdF4 shell UCNPs

Choose the anticancer drug, a pyrimidine antagonist

A

Fluorouracil

B

Mercaptopurine

C

Thioguanine

D

Methotrexate

Factors altering the binding of the drug to the blood increases the volume of distribution of the drug and the factors that influence drug binding to the extravascular component decreases the volume of distribution.

A

True

B

False

Which of the following is a correct method to find the fraction of unbound drug in plasma? Given where Cu is the concentration of unbound drug and C is total plasma drug concentration.

A

CuC

B

C / Cu

C

Cu/C

D

1/C Cu

For a certain drug, the bile flow rate is 0.7 ml/mm, the biliary drug concentration is 2g/ml and the plasma drug concentration is 0.8g/ml. What will be the bile clearance?

A

1.50 ml/mm

B

1.75 ml/mm

C

2.75 ml/mm

D

3 ml/mm

In a graph of rate of excretion versus plasma drug concentration, which kind of drug will give the below shown curve? (x axis- rate of excretion, y axis – plasma drug concentration)

A

Drug excreted only by filtration

B

Drug filtered and actively reabsorbed

C

Drug filtered as well as actively secreted

D

Drug reabsorbed actively

A drug was sold by an auction and according to the usage of trade it was to disclose in advance of any vast damage caused in the quality of the drug but such disclosure was not made and the drug was found to be defective. This is an example of:

A

Warranty as to undisturbed possession

B

Warranty as to quality or fitness by usage of trade

C

Warranty as to non-existence of encumbrances

D

Disclosure of dangerous nature of goods