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For a certain drug, the bile flow rate is 0.7 ml/mm, the biliary drug concentration is 2g/ml and the plasma drug concentration is 0.8g/ml. What will be the bile clearance?

Correct Answer: 1.75 ml/mm
The equation for bile clearance is biliary excretion rate/ plasma drug concentration. Since biliary excretion can also be written as bile flow * biliary drug concentration. The other equation for bile clearance is bile flow * biliary drug concentration/ plasma drug concentration. Thus the answer is 0.7*2*0.8=1.75 ml/mm.

In a graph of rate of excretion versus plasma drug concentration, which kind of drug will give the below shown curve? (x axis- rate of excretion, y axis – plasma drug concentration)

Which of the following is a correct method to find the fraction of unbound drug in plasma? Given where Cu is the concentration of unbound drug and C is total plasma drug concentration.

To have a plasma distribution value of 900 ml and plasma drug concentration to be 1.2 mg/ml what should be the amount of drug that should be given to the patient?

What will be the renal clearance ratio of a drug whose renal clearance is 40ml/min and the clearance of creatinine is 95ml/min?

In a graph of renal clearance versus plasma drug concentration, which kind of drug will give the below shown curve?

What will be the renal clearance if the rate of urinary excretion is 625 ml/min and plasma drug concentration is 4.2 ng/ml?

Which of the following statements are true/false?
1. A minimum rate of wages for the time spent by employees for the production of output is minimum time rate.
2. Minimum piece rate is the rate based on the quantity of the output employees have produced.
3. The guaranteed time rate is a minimum rate of remuneration to apply in the case of employees employed on piece work for the purpose of securing to such employees a minimum rate of wages on a time work basis.
4. A minimum rate of remuneration to apply in the case of employees employed on piece work for the purpose of securing to such employees a minimum rate of wages on a time work basis is overtime rate.

What will be the fraction of unbound drug if the unbound drug concentration is 0.99 g/ml and total plasma concentration is 160 g/ml?

What will be the unbound drug concentration if the unbound drug fraction is 0.52 and the total plasma concentration is 140 g/ml?

The renal clearance of a drug bound to plasma protein is increased after displacement with another drug.