Choose the anticancer drug, a pyrimidine antagonist

Substitution of a purine by a purine, of a pyrimidine by a pyrimidine, and of a base-pair by another base-pair which retains the original orientation of the purines and pyrimidines belongs to the class known as

A

Transversions

B

Transitions

C

Translocations

D

Translations

In an experimental study of the effects of a new drug on depression a double-blind control technique is used, which of the following persons should not be informed as to which drug, experimental or placebo is being administered to each individual research participant?
1. Research participants in the experimental group.
2. Research participants in the control group.
3. Persons administering the drug.
4. Persons evaluating the drug effect.
Select the correct answer:

A

Only 2

B

1 and 3

C

1, 2 and 4

D

All of these

Taxol is an anticancer drug obtained from Vinca rosea.

A

True

B

False

Which of these nanoprobes can detect cancer cell nuclei as well as deliver anticancer drug directly to the nuclei region?

A

PAA modified BaYbF5:Tm nanoprobes

B

Superparamagnetic iron oxide nanoprobes

C

PEG modified BaGdF5:YB/ER UCNPs

D

Er/Yb doped NaYF4 core and NaGdF4 shell UCNPs

The Pacific yew is an evergreen tree that grows in the Pacific Northwest. The Pacific yew has a fleshy, poisonous fruit. Recently, taxol, a substance found in the bark of the Pacific yew, was discovered to be a promising new anticancer drug.

A

Taxol is poisonous when taken by healthy people.

B

Taxol has cured people from various diseases.

C

People should not eat the fruit of the Pacific yew.

D

The Pacific yew was considered worthless until taxol was discovered.

What is the drug antagonist of estrogen?

A

Tanoxifen

B

Metformin

C

Glucophage

D

Victoza

A drug that is highly effective in treating many types of infection can,at present,be obtained only from the bark of the ibora , a tree that is quite rare in the wild. It takes the bark of 5000 trees to make one kilogram of the drug. It follows, therefore, that continued production of the drug must inevitably lead to the ibore's extinction. Which of the following,if true, most seriously weakens the arguments above ?

A

The drug made from the ibora bark is dispensed to doctors from a central authority

B

The drug made from the ibora bark is expensive to produce

C

The leaves of the ibora are used in a number of medical products

D

The ibora can be propagated from cuttings and grown under cultivation

Factors altering the binding of the drug to the blood increases the volume of distribution of the drug and the factors that influence drug binding to the extravascular component decreases the volume of distribution.

A

True

B

False

Which of the following is a correct method to find the fraction of unbound drug in plasma? Given where Cu is the concentration of unbound drug and C is total plasma drug concentration.

A

CuC

B

C / Cu

C

Cu/C

D

1/C Cu

For a certain drug, the bile flow rate is 0.7 ml/mm, the biliary drug concentration is 2g/ml and the plasma drug concentration is 0.8g/ml. What will be the bile clearance?

A

1.50 ml/mm

B

1.75 ml/mm

C

2.75 ml/mm

D

3 ml/mm