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Which type of porcine insulin is used in the treatment of diabetes mellitus?

A

De alaninated

B

De glycinated

C

De valinated

D

Threonine present

Correct Answer: De alaninated

Porcine Insulin, or pig insulin, is the most studied hormone and is a two-chain polypeptide hormone formed in vivo in pancreatic beta cells. The elimination of alanine (de-alaninated) maintains the biological function of porcine insulin. Due to the lower antigenicity, de-alaninated insulin has been used in treating diabetes mellitus.

Which of the following are associated with diabetes mellitus, a common disease in adults?
1. Higher sugar level in blood
2. Lower sugar level in blood
3. Lower insulin level in blood
4. Higher insulin level in blood

A

Only 2 and 4

B

Only 1 and 2

C

Only 2 and 3

D

Only 1 and 3

The difference between human insulin and porcine insulin is located in which amino acid?

A

Number 30 amino acid of A chain

B

Number 30 amino acid of B chain

C

Number 20 amino acid of A chain

D

Number 20 amino acid of B chain

The conversion of porcine insulin to human insulin is catalyzed by ________ enzyme.

A

thermolysin

B

trypsin

C

streptokinase

D

asparginase

The conversion of porcine insulin to human insulin is achieved by ____________ reaction.

A

hydrogenation

B

transpeptidation

C

kinetically controlled synthesis

D

decomposition

Diabetes Mellitus is caused by defects in insulin signaling.

A

True

B

False

Regarding treatment of diabetes mellitus

A

Pioglitazone acts as an insulin sensitizer

B

Peptidyl peptidase-IV inhibitor acts as insulin secretogogue

C

Dosage of insulin should be increased in patient with somogyi effect

D

Two insulin sensitizer cannot be given

E

Metformin cannot be given in non-obese patients

Type 1 diabetes mellitus

A

Shows seasonal incidence

B

Always requires insulin

C

Has strong familial predisposition

D

Is characterized by insulin resistance

E

Shows high level of C- peptide

Diabetes Mellitus type II is caused due __________________________

A

inability to produce insulin

B

insulin resistance

C

low glucose levels

D

low lactose levels

Type 2 diabetes mellitus arise due to the autoimmune destruction of pancreatic cells.

A

True

B

False

Type 2 diabetes mellitus occur due to

A

Deficiency of insulin

B

Inactivation of insulin receptors

C

Both of the above

D

None of the above