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The difference between human insulin and porcine insulin is located in which amino acid?

Correct Answer: Number 30 amino acid of B chain
Porcine insulin is identical to the insulin in humans. Only the terminal amino acid number 30 in the B-chain varies. It is alanine in place of threonine in the porcine insulin. Patients who have transitioned to human insulin have reported substantial reductions in the levels of anti-insulin antibodies, making insulin allergies easier to control.

In a batch process, the reaction takes place in the presence of an acid medium. The acid is drained from the reaction vessel at the rate of 15ml/s as a result of the density difference of the acid from the reacting component. To avoid wastage of acid, it is recycled to an acid tank which has 1000 L capacity. The acid drained from the reaction vessel, picks up 50 g/L solids from the reactor. Acid is fed once again to the process from acid tank. When the process is started, the acid is almost pure in the tank as a result of filtration. As the reaction proceeds, acid in the tank gets more and more contaminated with the solids. The concentration of the solids should not exceed 100 g/L from the process point of view. The batch time is 16h. Estimate whether the concentration of the solids will exceed 100g/L during the batch reaction.

"Too often we try to solve human problem with non-human tools and in terms of non-human data. It is my simple thesis that a human problem requires a human solution. First we have to learn to recognise a human problem when we see one; and second, upon recognising it, we have to learn to deal with it as such and not as it were something else. A human problem to be brought to a human solution requires human data and human tools". Who said this?

Consider the following statements regarding genetic code and choose the correct answer:
1. The genetic code is degenerate
2. In all amino acids the first two bases are the same in all the codons that represent a particular amino acid
3. The number of codons an amino acid can claim is proportional to the frequency of the amino acid in proteins
4. Amino acids with codons ending in U or A also have codons ending in C or G respectively

Analysis of a hexapeptide using enzymatic cleavage reveals the following result:
• Amino acid composition of the peptide is: 2R, A, V, S, Y
• Trypsin digestion yields two fragments and the compositions are: (R, A, V) and (R, S, Y)
• Chymotrypsin digestion yields two fragments and the compositions are: (A, R, V, Y) and (R, S)
• Digestion with carboxypeptidase A yields no cleavage product.
Given: Trypsin cleaves at carboxyl side of R. Chymotrypsin cleaves at carboxyl side of Y. Carboxypeptidase A cleaves at amino side of the C-terminal amino acid (except R and K) of the peptide.
The correct amino acid sequence of the peptide is:

The conversion of porcine insulin to human insulin is catalyzed by ________ enzyme.

The conversion of porcine insulin to human insulin is achieved by ____________ reaction.

PROTPARS counts the minimum number of mutations to change a codon for the first amino acid into a codon for the second amino acid, but only scores those mutations in the mutational path that actually change the amino acid.

Solution-1 containing 10% nitric acid and 20% acetic acid at the rate F combines with Solution-2 containing 20% nitric acid and 10% acetic acid at the rate D, the product formed contains 30% nitric acid and 20% acetic acid at the rate P, how many independent equations containing F, D, and P are possible?

Solution-1 containing 10% hydrochloric acid and 20% acetic acid at the rate F combines with Solution-2 containing 20% hydrochloric acid and 30% acetic acid at the rate D, the product formed contains 20% hydrochloric acid and 30% acetic acid at the rate P, how many independent equations containing F, D, and P are possible?

Which pancreatic hormone was initially isolated from porcine intestine as a 29-amino-acid, C-terminally amidated neuropeptide?