What is plasma creatinine? Why is it used as an index of kidney function?

Monjur Alahi

What is plasma creatinine? Why is it used as an index of kidney function?


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Salim Ahmed Kawsar

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1. Plasma creatinine is produced from catabolism of creatinine phosphate during skeletal muscle contraction.

2. It provides a ready source of high energy phosphate. 

3. Normally blood creatinine levels remain steady because the rate of production matches its excretion in urine. 

4. Hence, plasma creatinine is used as an index of kidney function and its level above normal is an indication of poor renal function. 

[Note: Plasma creatinine is a waste product produced by muscles from the breakdown of a compound called ‘creatine phosphate.]

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