In which stage of the cell cycle are histone proteins synthesised in a eukaryotic cells ?
A. During `G_(2)` - stage of prophase
B. During S-phase
C. During entire prophase
D. During telophase


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Correct Answer - B
During S-phase of cell cycle synthesis of histone proteins takes place because at this stage the amount of DNA per cell get double to that of somatic number. Histone proteins are basic (absent in prokaryotes) DNA. DNA and histones together comprise chromatin, forming bulk of the eukaryotic chromosomes. Histones are of five major kinds H1, H2A, H2B and H4. H1 histones link neighbouring nucleosomes.

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