Sonal while studying ETS had a doubt, why FADH2 yields only 2 ATP’s whereas NADH2 yields three ATP’s? What would be the correct explanation for her doubt?


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1. During ETS, NADH2 and FADH2 undergoes oxidation where they are converted to NAD+ and FAD+ respectively. 

2. During this conversion, hydrogen is removed, which latter forms proton and electron. This electron so formed is passed on to different electron carriers. During this transfer of electron, energy is released which is used in ATP synthesis. 

3. In case of NADH2, energy is released at three places hence results into formation of 3 ATPs whereas, in case of FADH2 energy is released at only two places, hence results into formation of only 2 ATPs. 

4. Here, the ATP formation occurs by Chemiosmotic hypothesis.

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