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The Apostolic Vicariate of Anatolia is a Roman Catholic Latin apostolic vicariate in the eastern half of Anatolia.

The missionary pre-diocesan jurisdiction is not part of any ecclesiastical province. It is under the direction of the Congregation for the Oriental Churches, an unusual structure for a Latin see, and directly dependent on the Holy See.

Its cathedral seat is the Marian Cathedral of the Annunciation in İskenderun. It has the Co-Cathedral of St. Anthony of Padua in Mersin as well.

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