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In protein structure prediction, statistical potentials or knowledge-based potentials are scoring functions derived from an analysis of known protein structures in the Protein Data Bank.
The original method to obtain such potentials is the quasi-chemical approximation, due to Miyazawa and Jernigan. It was later followed by the potential of mean force , developed by Sippl. Although the obtained scores are often considered as approximations of the free energy—thus referred to as pseudo-energies—this physical interpretation is incorrect. Nonetheless, they are applied with success in many cases, because they frequently correlate with actual Gibbs free energy differences.
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