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Phase space measurement with forward modeling is one approach to address the scattering issue in biomedical imaging. Scattering is one of the biggest problems in biomedical imaging, given that scattered light is eventually defocused, thus resulting in diffused images. Instead of removing the scattered light, this approach uses the information of scattered light to reconstruct the original light signals. This approach requires the phase space data of light in imaging system and a forward model to describe scattering events in a turbid medium. Phase space of light can be obtained by using digital micromirror device or light field microscopy. Phase space measurement with forward modeling can be used in neuroscience to record neuronal activity in the brain.