1. ChloroFluoroCarbons
  2. Polyphenols
  3. Dioxins
  4. Rayon

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Answer: Option 1

Chlorofluorocarbons (CFCs) and other halogenated ozone depleting substances (ODS) are mainly responsible for man-made chemical ozone depletion. The total amount of effective halogens (chlorine and bromine) in the stratosphere can be calculated and are known as the equivalent effective stratospheric chlorine (EESC).