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What is the role of carboxypeptidase B and trypsin-like peptidases in glucagon formation?

A

Inactivates glucagon

B

Hydrolyze proglucagon into glucagon

C

Helps in the breakdown of glucagon

D

Dehydrates glucagon

Correct Answer: Hydrolyze proglucagon into glucagon

In alpha-cells, glucagon is first synthesized as a pro-hormone, “proglucagon”. In alpha-cells, lysosomal enzyme peptidases such as carboxypeptidase B and trypsin-like peptidases hydrolyze pro-glucagon to generate glucagon and inactive peptides from both its N-terminal end and C-terminal end.

Which of the following statements relating to 'role' is/are true and false?
1 The system of various roles that the individual carries and performs is 'role set'.
2. The system of various roles of which an individuals role is a part in 'role space'.
3. Self role integration, proactivity, creativity and conformation are ingredients of the role making dimension of role efficacy.
4. Role stress is caused by both role space conflict and role set conflict.

A

1 and 3 are true, 2 and 4 are false

B

1 and 2 are true, 3 and 4 are false

C

1 and 2 are false, 3 and 4 are true

D

1 and 4 are true, 2 and 3 are false

Analysis of a hexapeptide using enzymatic cleavage reveals the following result:
• Amino acid composition of the peptide is: 2R, A, V, S, Y
• Trypsin digestion yields two fragments and the compositions are: (R, A, V) and (R, S, Y)
• Chymotrypsin digestion yields two fragments and the compositions are: (A, R, V, Y) and (R, S)
• Digestion with carboxypeptidase A yields no cleavage product.
Given: Trypsin cleaves at carboxyl side of R. Chymotrypsin cleaves at carboxyl side of Y. Carboxypeptidase A cleaves at amino side of the C-terminal amino acid (except R and K) of the peptide.
The correct amino acid sequence of the peptide is:

A

RSYRVA

B

AVRYSR

C

SRYVAR

D

SVRRYA

Assertion (A) Each role must have enough stressers which may help the role occupant to stretch himself/herself to meet the challenge. In the role, where the scope is limited to routine work, the role occupants do not perceive any challenge.
Reason (R) While every role has some routine elements, challenge can also be incorporated into every role. However, the challenge should not exceed an optimal limit, otherwise it may produce dysfunctional stress, resulting in poor performance or damage to the health of the employee in the long-run.

A

(A) and (R) both are true, (R) does not explains (A)

B

(A) and (R) both are true, (R) explains (A)

C

(A) is true, (R) does not explain (A)

D

(A) is not true, (R) explains (A)

Find out which of the figures 1, 2, 3 and 4 can be formed from the pieces given in figure (X).

A

1

B

2

C

3

D

4

Find out which of the figures 1, 2, 3 and 4 can be formed from the pieces given in figure (X).

A

1

B

2

C

3

D

4

Find out which of the figures 1, 2, 3 and 4 can be formed from the pieces given in figure (X).

A

1

B

2

C

3

D

4

Find out which of the figures 1, 2, 3 and 4 can be formed from the pieces given in figure (X).

A

1

B

2

C

3

D

4

Find out which of the figures 1, 2, 3 and 4 can be formed from the pieces given in figure (X).

A

1

B

2

C

3

D

4

Find out which of the figures 1, 2, 3 and 4 can be formed from the pieces given in figure (X).

A

1

B

2

C

3

D

4

Find out which of the figures 1, 2, 3 and 4 can be formed from the pieces given in figure (X).

A

1

B

2

C

3

D

4