Which of the following antigen factor is NOT considered for the activation and proliferation of B and T cells for carrying out the immune response?
Correct Answer: Its interaction with respective BCR and TCR
Depending on antigen parameters like quantity, quality (along with various parameters that determine the antigenic immunogenicity which includes size, structure, ability to induce cytokine responses after binding to non-clonal receptors on antigen-presenting cells, presentability of antigen fragments via major histocompatibility complex (MHC) molecules, etc.) route of entry, place of action in tissues, presence of natural microbial or mixed adjuvants, and the genetic constitution of the host: such interactions may either lead to activation and proliferation of the respective B and T cells that execute the immune response or may lead to differentiation into end stage effector and memory cells. These parameters can also cause induction of tolerance.