Cytotoxic immune response of NK cells leads to the release of which cytotoxic molecules?

The cytotoxic immune response of NK cells leads to the release of perforins and granzyme. This process is termed as degranulation. Cytotoxic response of NK cells starts by formation of synapse between target cells and NK cells. As soon as synapse formation takes place, secretory lysosomes are polarized towards the synapse. As and when they are directed towards the synapse, they get docked or tied up with Plasma Membrane of NK cells. Their tie up leads to targeting the cells in action. This completes the cytotoxic immune response.