Which is the right order of the steps involved in differentiation of T cells? i) Activated T cell generation into blast cell ii) Proliferation of blast cell iii) Differentiation of daughter cells iv) Differentiation into subsets of T cells
Correct Answer: i)—ii)—iii)—iv)
n: T cell differentiation starts after activation of T cell. The activated T cell then turns into a large blast cell mediated by developmental processes. This blast cell then proliferates by clonal expansion. (Clonal expansion is the process in which daughter cells arise from parent cell). This proliferation results in formation of daughter cells and they differentiate into effector (cytotoxic), memory and helper T cells. The helper T cells further differentiate into subsets of T cells.