What is the major difference between Central memory T cells (TCM Cells) and Effector memory T cells (TEM Cells)?

TCM cells can express CD45RO but TEM cells lack expression of CD45RO

TCM cells have a high affinity to express CD44 but TEM cells lack this affinity

TCM cells express C-C chemokine receptor type 7 (CCR7) and L-selectin while TEM cells lack this expression

TCM cells express CD45RO, CD44 and CCR7 while TEM cells lack expression of all three

Correct Answer: TCM cells express C-C chemokine receptor type 7 (CCR7) and L-selectin while TEM cells lack this expression

Central memory T cells (TCM cells) and Effector memory T cells (TEM cells), both can readily express CD45RO as well as CD4d) The only differentiating factor between both the cell subtypes is that TCM cells have the ability to express C-C chemokine receptor type 7 (CCR7) and L-selectin while TEM cells lack this expression. Another important differentiating factor between both cell subtypes is that TCM cells are commonly found in lymph nodes and hence they readily react to lymph node receptors while TEM cells do not react to lymph node receptors. Hence, they are found in peripheral circulation and tissues.