The amino-terminal domains of both heavy and light chains are variable; in that, they differ in amino acid sequence from antibody to antibody.

Correct Answer: True
The above statement is true. The amino-terminal domains of both heavy and light chains are variable; in that, they differ in amino acid sequence from antibody to antibody. The other domains are constant, that they have the same amino acid sequence for a given antibody chain of the same isotype except for a single amino acid difference at a few positions.